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Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation
The mechanisms by which the hereditary hemochromatosis protein, HFE, decreases transferrin-mediated iron uptake were examined. Coimmunoprecipitation studies using solubilized cell extracts demonstrated that transferrin (Tf) competed with HFE for binding to the transferrin receptor (TfR) similar to p...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC170947/ https://ncbi.nlm.nih.gov/pubmed/12874382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1233675100 |
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