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Insig-1 “brakes” lipogenesis in adipocytes and inhibits differentiation of preadipocytes

We have examined gene expression in the fat tissue of normal mice at the onset of diet-induced obesity. Insulin-induced gene 1 (insig-1) mRNA rose progressively with a high-fat diet and declined on a restricted diet. Because insig-1 binds sterol regulatory element-binding protein cleavage-activating...

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Bibliografiske detaljer
Main Authors: Li, Jinping, Takaishi, Kiyosumi, Cook, William, McCorkle, Sara Kay, Unger, Roger H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC170943/
https://ncbi.nlm.nih.gov/pubmed/12869692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1133426100
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