Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin

The biological function of Glu-181 in the photoactivation process of rhodopsin is explored through spectroscopic studies of site-specific mutants. Preresonance Raman vibrational spectra of the unphotolyzed E181Q mutant are nearly identical to spectra of the native pigment, supporting the view that G...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Yan, Elsa C. Y., Kazmi, Manija A., Ganim, Ziad, Hou, Jian-Min, Pan, Douhai, Chang, Belinda S. W., Sakmar, Thomas P., Mathies, Richard A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2003
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC170906/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12835420/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1531970100
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