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The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase

Lipoxygenase (LOX) enzymes form fatty acid hydroperoxides used in membrane remodeling and cell signaling. Mammalian epidermal LOX type 3 (eLOX3) is distinctive in totally lacking this typical oxygenase activity. Surprisingly, genetic evidence has linked mutations in eLOX3 or a colocalizing enzyme, 1...

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Autors principals: Yu, Zheyong, Schneider, Claus, Boeglin, William E., Marnett, Lawrence J., Brash, Alan R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC170889/
https://ncbi.nlm.nih.gov/pubmed/12881489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1633612100
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