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Endotoxin-induced lethality in neonatal mice is counteracted by interleukin-10 (IL-10) and exacerbated by anti-IL-10.

The lethal effects occurring in neonatal (<24-h-old) BALB/c mice after challenge with 25 mg of lipopolysaccharide (LPS) per kg of body weight were significantly counteracted by pretreatment with recombinant interleukin-10 (rIL-10; 25 or 50 ng/mouse). Concordantly, blockage of endogenous IL-10 with t...

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Udgivet i:Clin Diagn Lab Immunol
Principais autores: Nicoletti, F, Mancuso, G, Ciliberti, F A, Beninati, C, Carbone, M, Franco, S, Cusumano, V
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC170607/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9302214/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/cdli.4.5.607-610.1997
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