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Endotoxin-induced lethality in neonatal mice is counteracted by interleukin-10 (IL-10) and exacerbated by anti-IL-10.

The lethal effects occurring in neonatal (<24-h-old) BALB/c mice after challenge with 25 mg of lipopolysaccharide (LPS) per kg of body weight were significantly counteracted by pretreatment with recombinant interleukin-10 (rIL-10; 25 or 50 ng/mouse). Concordantly, blockage of endogenous IL-10 wit...

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Detalhes bibliográficos
Main Authors: Nicoletti, F, Mancuso, G, Ciliberti, F A, Beninati, C, Carbone, M, Franco, S, Cusumano, V
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC170607/
https://ncbi.nlm.nih.gov/pubmed/9302214
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