DNA Damage–Induced Bcl-x(L) Deamidation Is Mediated by NHE-1 Antiport Regulated Intracellular pH

The pro-survival protein Bcl-x(L) is critical for the resistance of tumour cells to DNA damage. We have previously demonstrated, using a mouse cancer model, that oncogenic tyrosine kinase inhibition of DNA damage–induced Bcl-x(L) deamidation tightly correlates with T cell transformation in vivo, alt...

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Detalhes bibliográficos
Main Authors: Zhao, Rui, Oxley, David, Smith, Trevor S, Follows, George A, Green, Anthony R, Alexander, Denis R
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1702560/
https://ncbi.nlm.nih.gov/pubmed/17177603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050001
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