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DNA Damage–Induced Bcl-x(L) Deamidation Is Mediated by NHE-1 Antiport Regulated Intracellular pH
The pro-survival protein Bcl-x(L) is critical for the resistance of tumour cells to DNA damage. We have previously demonstrated, using a mouse cancer model, that oncogenic tyrosine kinase inhibition of DNA damage–induced Bcl-x(L) deamidation tightly correlates with T cell transformation in vivo, alt...
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| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Public Library of Science
2007
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1702560/ https://ncbi.nlm.nih.gov/pubmed/17177603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050001 |
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