Use of thermolytic protective groups to prevent G-tetrad formation in CpG ODN type D: structural studies and immunomodulatory activity in primates

CpG oligodeoxynucleotides (ODN) show promise as immunoprotective agents and vaccine adjuvants. CpG ODN type D were shown to improve clinical outcome in rhesus macaques challenged with Leishmania major. These ODN have a self-complementary core sequence and a 3′ end poly(G) track that favors G-tetrad...

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Bibliographic Details
Main Authors: Puig, Montserrat, Grajkowski, Andrzej, Boczkowska, Malgorzata, Ausín, Cristina, Beaucage, Serge L., Verthelyi, Daniela
Format: Artigo
Language:Inglês
Published: Oxford University Press 2006
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1702498/
https://ncbi.nlm.nih.gov/pubmed/17130156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl867
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