Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC′ redefines the substrate-binding site and suggests a model for protein–RNA interactions

The Erm family of adenine-N(6) methyltransferases (MTases) is responsible for the development of resistance to macrolide–lincosamide–streptogramin B antibiotics through the methylation of 23S ribosomal RNA. Hence, these proteins are important potential drug targets. Despite the availability of the N...

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Vydáno v:	Nucleic Acids Res
Hlavní autoři:	Maravić, Gordana, Bujnicki, Janusz M., Feder, Marcin, Pongor, Sándor, Flögel, Mirna
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 2003
Témata:	Articles
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC169915/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12907737/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg666
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