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Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC′ redefines the substrate-binding site and suggests a model for protein–RNA interactions

The Erm family of adenine-N(6) methyltransferases (MTases) is responsible for the development of resistance to macrolide–lincosamide–streptogramin B antibiotics through the methylation of 23S ribosomal RNA. Hence, these proteins are important potential drug targets. Despite the availability of the N...

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Detalhes bibliográficos
Main Authors: Maravić, Gordana, Bujnicki, Janusz M., Feder, Marcin, Pongor, Sándor, Flögel, Mirna
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC169915/
https://ncbi.nlm.nih.gov/pubmed/12907737
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