Sequence–structure–function relationships of Tgs1, the yeast snRNA/snoRNA cap hypermethylase

The Saccharomyces cerevisiae Tgs1 methyltransferase (MTase) is responsible for conversion of the m(7)G caps of snRNAs and snoRNAs to a 2,2,7- trimethylguanosine structure. To learn more about the evolutionary origin of Tgs1 and to identify structural features required for its activity, we performed...

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Bibliographic Details
Main Authors: Mouaikel, John, Bujnicki, Janusz M., Tazi, Jamal, Bordonné, Rémy
Format: Artigo
Language:Inglês
Published: Oxford University Press 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC169889/
https://ncbi.nlm.nih.gov/pubmed/12907733
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