Down-Regulation of Ubiquitin Ligase Cbl Induced by Twist Haploinsufficiency in Saethre-Chotzen Syndrome Results in Increased PI3K/Akt Signaling and Osteoblast Proliferation

Genetic mutations of Twist, a basic helix-loop-helix transcription factor, induce premature fusion of cranial sutures in Saethre-Chotzen syndrome (SCS). We report here a previously undescribed mechanism involved in the altered osteoblastogenesis in SCS. Cranial osteoblasts from an SCS patient with a...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Guenou, Hind, Kaabeche, Karim, Dufour, Cécilie, Miraoui, Hichem, Marie, Pierre J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698848/
https://ncbi.nlm.nih.gov/pubmed/17003487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.060102
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados