NUB1 Suppresses the Formation of Lewy Body-Like Inclusions by Proteasomal Degradation of Synphilin-1

NUB1 is a potent down-regulator of the ubiquitin-like protein NEDD8, because it targets NEDD8 to the proteasome for proteolytic degradation. From results in this study, we found that NUB1 physically interacts with synphilin-1 through its NEDD8-binding site, implying that NUB1 also targets synphilin-...

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Hlavní autoři: Tanji, Kunikazu, Tanaka, Tomoaki, Mori, Fumiaki, Kito, Katsumi, Takahashi, Hitoshi, Wakabayashi, Koichi, Kamitani, Tetsu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2006
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698792/
https://ncbi.nlm.nih.gov/pubmed/16877356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051067
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