Regulation of Type II Collagen Synthesis during Osteoarthritis by Prolyl-4-Hydroxylases : Possible Influence of Low Oxygen Levels

Osteoarthritic (OA) chondrocytes are metabolically active, displaying increased synthesis of type II collagen. Here, we show by immunohistochemistry and polymerase chain reaction that in comparison with healthy cartilage, OA articular chondrocytes exhibit increased in vivo synthesis of collagen prol...

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Main Authors: Grimmer, Claudia, Balbus, Nadine, Lang, Ute, Aigner, Thomas, Cramer, Thorsten, Müller, Lutz, Swoboda, Bernd, Pfander, David
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2006
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Regular Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698781/
https://ncbi.nlm.nih.gov/pubmed/16877351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.050738
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