Protease-Activated Receptor-2 Activation in Gastric Cancer Cells Promotes Epidermal Growth Factor Receptor Trans-Activation and Proliferation

Dysregulated epidermal growth factor receptor (EGFR) signaling is involved in gastric cancer (GC) cell growth. However, the mechanism that sustains EGFR signaling in GC remains unknown. Since protease-activated receptor-2 (PAR-2), a G protein-coupled receptor, has been shown to trans-activate EGFR i...

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Main Authors: Caruso, Roberta, Pallone, Francesco, Fina, Daniele, Gioia, Valentina, Peluso, Ilaria, Caprioli, Flavio, Stolfi, Carmine, Perfetti, Alessandra, Giusto Spagnoli, Luigi, Palmieri, Giampiero, MacDonald, Thomas T., Monteleone, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2006
Assuntos:
Regular Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698759/
https://ncbi.nlm.nih.gov/pubmed/16816379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.050841
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