Protease-Activated Receptor-2 Activation in Gastric Cancer Cells Promotes Epidermal Growth Factor Receptor Trans-Activation and Proliferation

Dysregulated epidermal growth factor receptor (EGFR) signaling is involved in gastric cancer (GC) cell growth. However, the mechanism that sustains EGFR signaling in GC remains unknown. Since protease-activated receptor-2 (PAR-2), a G protein-coupled receptor, has been shown to trans-activate EGFR i...

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Bibliographische Detailangaben
Hauptverfasser: Caruso, Roberta, Pallone, Francesco, Fina, Daniele, Gioia, Valentina, Peluso, Ilaria, Caprioli, Flavio, Stolfi, Carmine, Perfetti, Alessandra, Giusto Spagnoli, Luigi, Palmieri, Giampiero, MacDonald, Thomas T., Monteleone, Giovanni
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2006
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Regular Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698759/
https://ncbi.nlm.nih.gov/pubmed/16816379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.050841
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