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Interleukin-21 in cancer immunotherapy: Friend or foe?

Interleukin (IL)-21, a cytokine produced by activated conventional CD4+ T lymphocytes and Natural Killer T cells, drives anti-tumor immunity in the skin and kidney. However IL-21 is also pro-inflammatory in many tissues and promotes colitis-associated colon cancer. Understanding the biology of IL-21...

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Autors principals: Stolfi, Carmine, Pallone, Francesco, MacDonald, Thomas T., Monteleone, Giovanni
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382872/
https://ncbi.nlm.nih.gov/pubmed/22737612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.19122
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