IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1α activity

A central means by which mammalian cells respond to low oxygen tension is through the activation of the transcription factor HIF-1 (hypoxia-inducible factor-1). Under normoxic conditions, HIF-1α (the α subunit of HIF-1) is targeted for rapid degradation by the ubiquitin–proteasome pathway. Under hyp...

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Hlavní autoři: Huang, Jianhe, Song, Daisheng, Flores, Adrian, Zhao, Quan, Mooney, Sharon M., Shaw, Leslie M., Lee, Frank S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2006
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698691/
https://ncbi.nlm.nih.gov/pubmed/16956324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060635
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