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The activity of the dinuclear cobalt-β-lactamase from Bacillus cereus in catalysing the hydrolysis of β-lactams

Metallo-β-lactamases are native zinc enzymes that catalyse the hydrolysis of β-lactam antibiotics, but are also able to function with cobalt(II) and require one or two metal-ions for catalytic activity. The hydrolysis of cefoxitin, cephaloridine and benzylpenicillin catalysed by CoBcII (cobalt-subst...

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Autori principali: Badarau, Adriana, Damblon, Christian, Page, Michael I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698674/
https://ncbi.nlm.nih.gov/pubmed/16961465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061002
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