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Dimerization of the IκB Kinase-Binding Domain of NEMO Is Required for Tumor Necrosis Factor Alpha-Induced NF-κB Activity

Previous studies have demonstrated that peptides corresponding to a six-amino-acid NEMO-binding domain from the C terminus of IκB kinase alpha (IKKα) and IKKβ can disrupt the IKK complex and block NF-κB activation. We have now mapped and characterized the corresponding amino-terminal IKK-binding dom...

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書目詳細資料
Main Authors: Marienfeld, Ralf B., Palkowitsch, Lysann, Ghosh, Sankar
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698548/
https://ncbi.nlm.nih.gov/pubmed/17000764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00478-06
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