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Nucleostemin Delays Cellular Senescence and Negatively Regulates TRF1 Protein Stability
Nucleostemin (NS) encodes a nucleolar GTP-binding protein highly enriched in the stem cells and cancer cells. To determine its biological activity in vivo, we generated NS loss- and gain-of-function mouse models. The embryogenesis of homozygous NS-null (NS(−/−)) mice was aborted before the blastula...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1698521/ https://ncbi.nlm.nih.gov/pubmed/17000763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00724-06 |
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