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Efficient Incorporation of Multiple Selenocysteines Involves an Inefficient Decoding Step Serving as a Potential Translational Checkpoint and Ribosome Bottleneck

Selenocysteine is incorporated into proteins via “recoding” of UGA from a stop codon to a sense codon, a process that requires specific secondary structures in the 3′ untranslated region, termed selenocysteine incorporation sequence (SECIS) elements, and the protein factors that they recruit. Wherea...

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Detalhes bibliográficos
Main Authors: Stoytcheva, Zoia, Tujebajeva, Rosa M., Harney, John W., Berry, Marla J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698516/
https://ncbi.nlm.nih.gov/pubmed/17000762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00856-06
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