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Genetic Architecture of Hsp90-Dependent Drug Resistance

Hsp90 potentiates the evolution of azole resistance in the model yeast Saccharomyces cerevisiae and the opportunistic pathogen Candida albicans via calcineurin. Here, we explored effectors downstream of calcineurin regulating this Hsp90-dependent trait. Using S. cerevisiae erg3 mutants as a model, w...

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Main Authors: Cowen, Leah E., Carpenter, Anne E., Matangkasombut, Oranart, Fink, Gerald R., Lindquist, Susan
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1694807/
https://ncbi.nlm.nih.gov/pubmed/17056742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00274-06
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