Position-dependent effects of locked nucleic acid (LNA) on DNA sequencing and PCR primers

Genomes are becoming heavily annotated with important features. Analysis of these features often employs oligonucleotides that hybridize at defined locations. When the defined location lies in a poor sequence context, traditional design strategies may fail. Locked Nucleic Acid (LNA) can enhance olig...

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Detalles Bibliográficos
Main Authors: Levin, Joshua D., Fiala, Dean, Samala, Meinrado F., Kahn, Jason D., Peterson, Raymond J.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2006
Assuntos:
Methods Online
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1694044/
https://ncbi.nlm.nih.gov/pubmed/17071964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl756
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