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Mutations in the E9L Polymerase Gene of Cidofovir-Resistant Vaccinia Virus Strain WR Are Associated with the Drug Resistance Phenotype

Cidofovir (CDV) is an effective drug against viruses of the Orthopoxviridae family and is active in vitro against variola virus, the cause of smallpox. However, CDV-resistant poxviruses can be generated by repeated in vitro passage in the presence of suboptimal concentrations of CDV. To determine if...

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Bibliografiske detaljer
Main Authors: Kornbluth, Richard S., Smee, Donald F., Sidwell, Robert W., Snarsky, Victoria, Evans, David H., Hostetler, Karl Y.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1694007/
https://ncbi.nlm.nih.gov/pubmed/16982794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00380-06
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