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Mutations in the E9L Polymerase Gene of Cidofovir-Resistant Vaccinia Virus Strain WR Are Associated with the Drug Resistance Phenotype

Cidofovir (CDV) is an effective drug against viruses of the Orthopoxviridae family and is active in vitro against variola virus, the cause of smallpox. However, CDV-resistant poxviruses can be generated by repeated in vitro passage in the presence of suboptimal concentrations of CDV. To determine if...

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Detalhes bibliográficos
Main Authors: Kornbluth, Richard S., Smee, Donald F., Sidwell, Robert W., Snarsky, Victoria, Evans, David H., Hostetler, Karl Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1694007/
https://ncbi.nlm.nih.gov/pubmed/16982794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00380-06
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