Both introns and long 3′-UTRs operate as cis-acting elements to trigger nonsense-mediated decay in plants

Nonsense-mediated mRNA decay (NMD) is a eukaryotic quality control mechanism that identifies and eliminates aberrant mRNAs containing a premature termination codon (PTC). Although, key trans-acting NMD factors, UPF1, UPF2 and UPF3 are conserved in yeast and mammals, the cis-acting NMD elements are d...

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Detalhes bibliográficos
Main Authors: Kertész, Sándor, Kerényi, Zoltán, Mérai, Zsuzsanna, Bartos, Imre, Pálfy, Tamás, Barta, Endre, Silhavy, Dániel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2006
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1693880/
https://ncbi.nlm.nih.gov/pubmed/17088291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl737
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