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Smad4 cooperates with lymphoid enhancer-binding factor 1/T cell-specific factor to increase c-myc expression in the absence of TGF-β signaling
The c-myc protooncogene is a key regulator of cell proliferation whose expression is reduced in normal epithelial cells in response to the growth inhibitory cytokine TGF-β. Smad4 mediates this inhibitory effect of TGF-β by forming a complex with Smad3, E2F4/5, and p107 at the TGF-β inhibitory elemen...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1693705/ https://ncbi.nlm.nih.gov/pubmed/17132729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604773103 |
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