An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice

In addition to nitric oxide (NO) and prostacyclin (PGI(2)), the endothelium generates the endothelium-derived hyperpolarizing factor (EDHF). We set out to determine whether an EDHF-like response can be detected in wild-type (WT) and endothelial NO synthase knockout mice (eNOS −/−) mice. Vasodilator...

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Main Authors: Brandes, Ralf P., Schmitz-Winnenthal, Friedrich-Hubertus, Félétou, Michel, Gödecke, Axel, Huang, Paul L., Vanhoutte, Paul M., Fleming, Ingrid, Busse, Rudi
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC16936/
https://ncbi.nlm.nih.gov/pubmed/10944233
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