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Major histocompatibility complex controls the trajectory but not host-specific adaptation during virulence evolution of the pathogenic fungus Cryptococcus neoformans.

Genes of the major histocompatibility complex (MHC) play a critical role in immune recognition and are the most genetically diverse loci known. One hypothesis to explain this diversity postulates that pathogens adapt to common MHC haplotypes and thus favour selection of new or rare alleles. To deter...

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Detalhes bibliográficos
Main Authors: McClelland, Erin E., Adler, Frederick R., Granger, Donald L., Potts, Wayne K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1691764/
https://ncbi.nlm.nih.gov/pubmed/15306300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rspb.2004.2736
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