Htra2-β1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2)

Spinal muscular atrophy (SMA), a common motor neuron disease in humans, results from loss of functional survival motor neuron (SMN1) alleles. A nearly identical copy of the gene, SMN2, fails to provide protection from SMA because of a single translationally silent nucleotide difference in exon 7. Th...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Hofmann, Yvonne, Lorson, Christian L., Stamm, Stefan, Androphy, Elliot J., Wirth, Brunhilde
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2000
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC16914/
https://ncbi.nlm.nih.gov/pubmed/10931943
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk