Enhanced Production of Insulin-Like Growth Factor I Fusion Protein in Escherichia coli by Coexpression of the Down-Regulated Genes Identified by Transcriptome Profiling

The transcriptome profiles of recombinant Escherichia coli producing human insulin-like growth factor I fusion protein (IGF-I(f)) during the high-cell-density fed-batch culture were analyzed using DNA microarrays. The expression levels of 529 genes were significantly altered after induction. About 2...

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Publié dans:	Appl Environ Microbiol
Auteurs principaux:	Choi, Jong Hyun, Lee, Sang Jun, Lee, Seok Jae, Lee, Sang Yup
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2003
Sujets:	Physiology and Biotechnology
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC169106/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12902266/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.69.8.4737-4742.2003
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