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Enhanced Production of Insulin-Like Growth Factor I Fusion Protein in Escherichia coli by Coexpression of the Down-Regulated Genes Identified by Transcriptome Profiling

The transcriptome profiles of recombinant Escherichia coli producing human insulin-like growth factor I fusion protein (IGF-I(f)) during the high-cell-density fed-batch culture were analyzed using DNA microarrays. The expression levels of 529 genes were significantly altered after induction. About 2...

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Detalhes bibliográficos
Main Authors: Choi, Jong Hyun, Lee, Sang Jun, Lee, Seok Jae, Lee, Sang Yup
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC169106/
https://ncbi.nlm.nih.gov/pubmed/12902266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.69.8.4737-4742.2003
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