Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids

Glucocorticoids (GCs) are potent anti-inflammatory agents that block cytokine production. We investigated whether GCs also block cytokine signaling via the Janus kinase (Jak)-signal transducer and activator of transcription (STAT) pathway. Dexamethasone inhibited IL-2-induced DNA binding, tyrosine p...

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Bibliographic Details
Main Authors: Bianchi, Marina, Meng, Charis, Ivashkiv, Lionel B.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC16906/
https://ncbi.nlm.nih.gov/pubmed/10920190
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