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Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40
Macrophages from Tpl2 knockout (Tpl2(–/–)) mice exhibit a defect in ERK activation by lipopolysaccharide (LPS). This impairs the nucleocytoplasmic transport of the tumor necrosis factor α (TNF-α) mRNA and prevents the induction of TNF-α by LPS. As a result, Tpl2(–/–) mice are resistant to LPS/d-gala...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC169059/ https://ncbi.nlm.nih.gov/pubmed/12881420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg386 |
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