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Estimating transition rates in aggregated Markov models of ion channel gating with loops and with nearly equal dwell times
A typical task in the application of aggregated Markov models to ion channel data is the estimation of the transition rates between the states. Realistic models for ion channel data often have one or more loops. We show that the transition rates of a model with loops are not identifiable if the mode...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1999
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1690217/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rspb.1999.0867 |
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