Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features

A 2.5-Å resolution structure of calcium-free calmodulin (CaM) bound to the first two IQ motifs of the murine myosin V heavy chain reveals an unusual CaM conformation. The C-terminal lobe of each CaM adopts a semi-open conformation that grips the first part of the IQ motif (IQxxxR), whereas the N-ter...

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Detaylı Bibliyografya
Asıl Yazarlar: Houdusse, Anne, Gaucher, Jean-François, Krementsova, Elena, Mui, Suet, Trybus, Kathleen M., Cohen, Carolyn
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2006
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1687203/
https://ncbi.nlm.nih.gov/pubmed/17151196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609436103
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