Development of a somatic mutation screening system using Hb mutants. IV. Successful detection of red cells containing the human frameshift mutants Hb Wayne and Hb Cranston using monospecific fluorescent antibodies.

The production and purification of antibodies detecting Hb Wayne, an alpha-globin frameshift mutant, and Hb Cranston, a beta-globin frameshift mutant, are described. The antibodies are of a nonprecipitating nature, and they permit strong fluorescent labeling of erythrocytes containing Hb Wayne or Hb...

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Detalhes bibliográficos
Main Authors: Stamatoyannopoulos, G, Nute, P E, Papayannopoulou, T, McGuire, T, Lim, G, Bunn, H F, Rucknagel, D
Formato: Artigo
Idioma:Inglês
Publicado em: 1980
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1686139/
https://ncbi.nlm.nih.gov/pubmed/6994493
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