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Reduction of bias in estimating the frequency of recessive genes.
The standard approach to estimating the frequency of a completely recessive autosomal gene is to use the maximum-likelihood estimator (MLE), q = square root q2. Since the expectation oof Q using MLE is systematically less than the true value, this estimator always gives a negatively biased estimate...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
1980
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1686013/ https://ncbi.nlm.nih.gov/pubmed/7386457 |
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