Diagnosis and carrier detection of Tay-Sachs disease: direct determination of hexosaminidase A using 4-methylumbelliferyl derivatives of beta-N-acetylglucosamine-6-sulfate and beta-N-acetylgalactosamine-6-sulfate.

4-Methylumbelliferyl-6-sulfo-2-acetamido-2-deoxy derivatives of beta-D glucopyranoside and beta-D-galactopyranoside were prepared by direct sulfation of the commonly used unsulfated derivatives. Both sulfated substrates were highly specific for hexosaminidase A, and in fractionated serum, cells, and...

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Bibliographische Detailangaben
Hauptverfasser: Ben-Yoseph, Y, Reid, J E, Shapiro, B, Nadler, H L
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1985
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1684631/
https://ncbi.nlm.nih.gov/pubmed/9556661
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