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Strategies and sample-size considerations for mapping a two-locus autosomal recessive disorder.
The problem of detecting linkage, by using the LOD-score method, of polymorphic marker loci to a disorder that is determined by recessive alleles at two independent autosomal diallelic loci has been considered. The expected LOD score and the distribution of the LOD score have been worked out for var...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1989
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1683398/ https://ncbi.nlm.nih.gov/pubmed/2773934 |
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