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Why does the human factor IX gene have a G + C content of 40%?

The factor IX gene has a G + C content of approximately 40% in all mammalian species examined. In human factor IX, C----T and G----A transitions at the dinucleotide CpG are elevated at least 24-fold relative to other transitions. Can the G + C content be explained solely by this hot spot of mutation...

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Detalhes bibliográficos
Main Authors: Bottema, C D, Bottema, M J, Ketterling, R P, Yoon, H S, Janco, R L, Phillips, J A, Sommer, S S
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1683181/
https://ncbi.nlm.nih.gov/pubmed/1897528
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