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Study of large inbred Friedreich ataxia families reveals a recombination between D9S15 and the disease locus

Friedreich ataxia is a neurodegenerative disorder with autosomal recessive inheritance. Precise linkage mapping of the Friedreich ataxia locus (FRDA) in 9q13-q21 should lead to the isolation of the defective gene by positional cloning. The two closest DNA markers, D9S5 and D9S15, show very tight lin...

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Detalhes bibliográficos
Main Authors: Belal, Samir, Panayides, Kyproula, Sirugo, Giorgio, Hamida, Christiane Ben, Ioannou, Panos, Hentati, Fayçal, Beckmann, Jacques, Koenig, Michel, Mandel, Jean-Louis, Hamida, Mongi Ben, Middleton, Lefkos T.
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1682916/
https://ncbi.nlm.nih.gov/pubmed/1463017
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