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Evolutionary origin of mutations in the primate cytochrome P450c21 gene.
The CYP21 gene codes for the enzyme cytochrome P450c21 (21-hydroxylase), which is critically involved in the synthesis of glucocorticoids and mineralocorticoids. Standard human haplotypes contain two copies of CYP21--a functional gene and a pseudogene. Inactivation of the functional gene leads to co...
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Main Authors: | , , |
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格式: | Artigo |
語言: | Inglês |
出版: |
1992
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1682642/ https://ncbi.nlm.nih.gov/pubmed/1550121 |
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