Down-regulation of p21(WAF1/CIP1) or p27(Kip1) abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells

Estrogens and antiestrogens influence the G(1) phase of the cell cycle. In MCF-7 breast cancer cells, estrogen stimulated cell cycle progression through loss of the kinase inhibitor proteins (KIPs) p27 and p21 and through G(1) cyclin-dependent kinase (cdk) activation. Treatment with antiestrogen dru...

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Bibliografiske detaljer
Main Authors: Cariou, Sandrine, Donovan, Jeffrey C. H., Flanagan, W. M., Milic, Andrea, Bhattacharya, Nandita, Slingerland, Joyce M.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC16818/
https://ncbi.nlm.nih.gov/pubmed/10908655
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