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Substitutions in the Reverse Transcriptase and Protease Genes of HIV-1 Subtype B in Untreated Individuals and Patients Treated With Antiretroviral Drugs

ABSTRACT: The nucleotide transition G→A is known as a hypermutation due to its high prevalence in HIV-1 and other pathogens. However, the contribution of the G→A transition in the generation of drug resistance mutations is unknown. Our objective was to ascertain the rate of nucleotide substitutions...

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Autors principals: Turner, Dan, Brenner, Bluma, Moisi, Daniela, Liang, Chen, Wainberg, Mark A.
Format: Artigo
Idioma:Inglês
Publicat: Medscape 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1681388/
https://ncbi.nlm.nih.gov/pubmed/16369374
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