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Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family

Friedreich ataxia is an autosomal recessive neurodegenerative disease caused by defects in the FRDA gene, which encodes a mitochondrial protein called frataxin. Frataxin is evolutionarily conserved, with homologs identified in mammals, worms, yeast, and bacteria. The CyaY proteins of γ-purple bacter...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Cho, Seung-Je, Lee, Myong Gyong, Yang, Jin Kuk, Lee, Jae Young, Song, Hyun Kyu, Suh, Se Won
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16799/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10908679/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.160270897
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