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Construction and Mutagenesis of an Artificial Bicistronic Tick-Borne Encephalitis Virus Genome Reveals an Essential Function of the Second Transmembrane Region of Protein E in Flavivirus Assembly

Flaviviruses have a monopartite positive-stranded RNA genome, which serves as the sole mRNA for protein translation. Cap-dependent translation produces a polyprotein precursor that is co- and posttranslationally processed by proteases to yield the final protein products. In this study, using tick-bo...

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מידע ביבליוגרפי
Main Authors: Orlinger, Klaus K., Hoenninger, Verena M., Kofler, Regina M., Mandl, Christian W.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2006
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1676298/
https://ncbi.nlm.nih.gov/pubmed/17035331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01540-06
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