Immunogenicity of Heterologous Recombinant Adenovirus Prime-Boost Vaccine Regimens Is Enhanced by Circumventing Vector Cross-Reactivity

The high prevalence of preexisting immunity to adenovirus serotype 5 (Ad5) in human populations has led to the development of recombinant adenovirus (rAd) vectors derived from rare Ad serotypes as vaccine candidates for human immunodeficiency virus type 1 and other pathogens. Vaccine vectors have be...

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Bibliographic Details
Main Authors: Thorner, Anna R., Lemckert, Angelique A. C., Goudsmit, Jaap, Lynch, Diana M., Ewald, Bonnie A., Denholtz, Matthew, Havenga, Menzo J. E., Barouch, Dan H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1676272/
https://ncbi.nlm.nih.gov/pubmed/17035318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01749-06
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