Identification of a C-Terminal Regulatory Motif in Hepatitis C Virus RNA-Dependent RNA Polymerase: Structural and Biochemical Analysis

The NS5B RNA-dependent RNA polymerase encoded by the hepatitis C virus (HCV) is a key component of the viral replicase. Reported here is the three-dimensional structure of HCV NS5B polymerase, with the highlight on its C-terminal folding, determined by X-ray crystallography at 2.1-Å resolution. Stru...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Lévêque, Vincent J.-P., Johnson, Robert B., Parsons, Stephen, Ren, Jianxin, Xie, Congping, Zhang, Faming, Wang, Q. May
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Replication
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC167210/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12885918/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.16.9020-9028.2003
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