Structural basis for sequence-dependent recognition of colicin E5 tRNase by mimicking the mRNA–tRNA interaction

Colicin E5—a tRNase toxin—specifically cleaves QUN (Q: queuosine) anticodons of the Escherichia coli tRNAs for Tyr, His, Asn and Asp. Here, we report the crystal structure of the C-terminal ribonuclease domain (CRD) of E5 complexed with a substrate analog, namely, dGpdUp, at a resolution of 1.9 Å. T...

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Autores principales: Yajima, Shunsuke, Inoue, Sakura, Ogawa, Tetsuhiro, Nonaka, Takamasa, Ohsawa, Kanju, Masaki, Haruhiko
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2006
Materias:
Structural Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1669751/
https://ncbi.nlm.nih.gov/pubmed/17099236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl729
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